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Three Subsequent Single Doses of Gadolinum Chelate for Brain MR Imaging in Multiple Sclerosis AJNR 24:658-662, Sardanelli,F.,et al, 2003 See this aricle in Pubmed Article Abstract With three subsequent SD injections, the number of enhancing lesions progressively increases. This approach allows the distinction of three levels of enhancement, and it reduces the amount of contrast agent needed to distinguish patients with active MS from those with nonactive MS.

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